FTSJ3

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 is an enzyme, an O-methyltransferase, that in humans is encoded by the FTSJ3 gene.

FTSJ3
Identifiers
Aliases	FTSJ3, EPCS3, SPB1, FtsJ homolog 3, FtsJ RNA methyltransferase homolog 3, FtsJ RNA 2'-O-methyltransferase 3
External IDs	OMIM: 618411; MGI: 1860295; HomoloGene: 5451; GeneCards: FTSJ3; OMA:FTSJ3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q23.3 Start 63,819,433 bp End 63,830,012 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 E1|11 68.89 cM Start 106,139,968 bp End 106,146,905 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve tendon of biceps brachii stromal cell of endometrium gastric mucosa right ovary right adrenal gland right lobe of thyroid gland body of uterus canal of the cervix Top expressed in tail of embryo genital tubercle epiblast ventricular zone yolk sac blastocyst embryo zygote morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity rRNA methyltransferase activity protein binding RNA binding rRNA (uridine-2'-O-)-methyltransferase activity rRNA (guanine) methyltransferase activity Cellular component nucleus nucleolus preribosome, large subunit precursor preribosome, small subunit precursor Biological process rRNA processing methylation RNA methylation ribosome biogenesis maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA methylation enzyme-directed rRNA 2'-O-methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117246 56095 Ensembl ENSG00000108592 ENSMUSG00000020706 UniProt Q8IY81 Q9DBE9 RefSeq (mRNA) NM_017647 NM_025310 RefSeq (protein) NP_060117 NP_079586 Location (UCSC) Chr 17: 63.82 – 63.83 Mb Chr 11: 106.14 – 106.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The enzyme performs 2′-O-methylation of RNA using S-adenosylmethionine as methyl donor.

Further reading

• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.