Frizzled-2

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.

FZD2
Identifiers
Aliases	FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
External IDs	OMIM: 600667; MGI: 1888513; HomoloGene: 20377; GeneCards: FZD2; OMA:FZD2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 44,557,484 bp End 44,561,262 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E1 Start 102,495,222 bp End 102,498,884 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo spinal ganglia ganglionic eminence stromal cell of endometrium trigeminal ganglion glomerulus metanephric glomerulus retinal pigment epithelium right coronary artery Top expressed in external carotid artery internal carotid artery ureter medullary collecting duct mandibular prominence vas deferens fossa maxillary prominence condyle ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component cytoplasm clathrin-coated endocytic vesicle membrane membrane focal adhesion plasma membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway epithelial cell differentiation muscular septum morphogenesis ventricular septum morphogenesis cell-cell signaling membranous septum morphogenesis outflow tract morphogenesis positive regulation of DNA-binding transcription factor activity Wnt signaling pathway planar cell polarity pathway involved in neural tube closure positive regulation of transcription, DNA-templated multicellular organism development sensory perception of smell cell surface receptor signaling pathway inner ear receptor cell development hard palate development cochlea morphogenesis neuron differentiation canonical Wnt signaling pathway signal transduction beta-catenin destruction complex disassembly Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway positive regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2535 57265 Ensembl ENSG00000180340 ENSMUSG00000050288 UniProt Q14332 Q9JIP6 RefSeq (mRNA) NM_001466 NM_020510 RefSeq (protein) NP_001457 NP_065256 Location (UCSC) Chr 17: 44.56 – 44.56 Mb Chr 11: 102.5 – 102.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.

Further reading

• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells. 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624. S2CID 40902391.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• "Frizzled Receptors: FZD₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.