Frizzled-3

Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.

FZD3
Identifiers
Aliases	FZD3, Fz-3, frizzled class receptor 3
External IDs	OMIM: 606143; MGI: 108476; HomoloGene: 23004; GeneCards: FZD3; OMA:FZD3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.1 Start 28,494,205 bp End 28,574,267 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 D1|14 34.09 cM Start 65,429,898 bp End 65,499,912 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 secondary oocyte corpus epididymis middle temporal gyrus endothelial cell entorhinal cortex parietal lobe postcentral gyrus cerebellar vermis buccal mucosa cell Top expressed in medial ganglionic eminence Rostral migratory stream anterior amygdaloid area olfactory tubercle ventromedial nucleus vestibular sensory epithelium trigeminal ganglion substantia nigra lateral septal nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding signal transducer activity Wnt-protein binding protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-activated receptor activity Cellular component cytoplasm lateral plasma membrane membrane plasma membrane apical part of cell presynaptic active zone cell surface axon filopodium tip soma dendrite apical plasma membrane integral component of membrane Biological process hair follicle development dopaminergic neuron axon guidance positive regulation of neuroblast proliferation sympathetic ganglion development G protein-coupled receptor signaling pathway negative regulation of execution phase of apoptosis negative regulation of mitotic cell cycle, embryonic serotonergic neuron axon guidance establishment of planar polarity cell proliferation in midbrain neuron migration Wnt signaling pathway commissural neuron axon guidance nervous system development multicellular organism development neural tube closure cell surface receptor signaling pathway inner ear morphogenesis neuron differentiation post-anal tail morphogenesis canonical Wnt signaling pathway midbrain morphogenesis midbrain development signal transduction response to electrical stimulus Wnt signaling pathway, calcium modulating pathway brain development planar cell polarity pathway involved in axon guidance Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7976 14365 Ensembl ENSG00000104290 ENSMUSG00000007989 UniProt Q9NPG1 Q61086 RefSeq (mRNA) NM_017412 NM_145866 NM_021458 RefSeq (protein) NP_059108 NP_665873 NP_067433 Location (UCSC) Chr 8: 28.49 – 28.57 Mb Chr 14: 65.43 – 65.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.

See also

• Frizzled

Further reading

• Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.
• Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
• Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436. S2CID 109984.
• Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031. S2CID 33599450.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders". Journal of Neural Transmission. 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645. S2CID 22324795.

External links

• "Frizzled Receptors: FZD₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.