Sodium ferric gluconate complex

Sodium ferric gluconate complex
Clinical data
Trade names	Ferrlecit
AHFS/Drugs.com	Monograph
MedlinePlus	a614030
License data	US DailyMed: Ferrlecit;
Routes of; administration	Intravenous (IV)
ATC code	B03AC (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	34089-81-1 ;
PubChem CID	76968835;
DrugBank	DB09517;
ChemSpider	34989638;
UNII	CC9149U2QX;
KEGG	D05859;
CompTox Dashboard (EPA)	DTXSID80187686 ;
Chemical and physical data
Formula	C66H121Fe2NaO65
Molar mass	2089.309 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@H]([C@@H](O)C(O[Na])=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O1)=O)[C@H](O)[C@H](O)CO.[Fe]1(OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO;
	InChI InChI=1S/5C12H22O11.C6H12O7.2Fe.Na.3O/c513-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12;7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;/h54-11,13-20H,1-3H2;2-5,7-11H,1H2,(H,12,13);;;;;;/q;;;;;;2+3;+1;3-2/p-1/t5*4-,5-,6-,7-,8+,9-,10+,11-,12+;2-,3-,4+,5-;;;;;;/m111111....../s1; Key:MQBDAEHWGRMADS-XNHLMZCASA-M;

Sodium ferric gluconate complex, sold under the brand name Ferrlecit, is an intravenously administered iron medication for the treatment of iron deficiency anemia in adults and in children aged six years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.^[2] The macromolecule has an apparent molecular weight of 289,000–440,000 Dalton.^[3]^[4]

The most common side effects in adults are nausea, vomiting and/or diarrhea, injection site reaction, hypotension, cramps, hypertension, dizziness, dyspnea, chest pain, leg cramps, and pain.^[2] In children the most common side effects are hypotension, headache, hypertension, tachycardia and vomiting.^[2]

References

^ "Sodium ferric gluconate complex Use During Pregnancy". Drugs.com. 16 December 2019. Retrieved 2 April 2020.
^ ^a ^b ^c "Ferrlecit- sodium ferric gluconate complex injection". DailyMed. 25 September 2019. Retrieved 2 April 2020.
^ "Sodium ferric gluconate complex". www.drugbank.ca. Retrieved 21 June 2020.^{[title missing]}
^ Fishbane S, Wagner J (May 2001). "Sodium ferric gluconate complex in the treatment of iron deficiency for patients on dialysis". American Journal of Kidney Diseases. 37 (5): 879–83. doi:10.1016/s0272-6386(05)80001-0. PMID 11325667.

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[Drugs.com_pregnancy-1] "Sodium ferric gluconate complex Use During Pregnancy". Drugs.com. 16 December 2019. Retrieved 2 April 2020.

[Ferrlecit_FDA_label-2] "Ferrlecit- sodium ferric gluconate complex injection". DailyMed. 25 September 2019. Retrieved 2 April 2020.

[3] "Sodium ferric gluconate complex". www.drugbank.ca. Retrieved 21 June 2020.^{[title missing]}

[Fishbane_2001-4] Fishbane S, Wagner J (May 2001). "Sodium ferric gluconate complex in the treatment of iron deficiency for patients on dialysis". American Journal of Kidney Diseases. 37 (5): 879–83. doi:10.1016/s0272-6386(05)80001-0. PMID 11325667.

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