NMR structure of ubiquitin (orange) in complex with the ubiquitin-associated (UBA) domain of ubiquilin-1 (cyan). All 10 models of the NMR ensemble are shown. Isoleucine 44, the center of a hydrophobic patch on the ubiquitin surface, is shown in blue, highlighting its role in interactions with the UBA domain. Rendered from PDB ID 2JY6 using Pymol (open source version 2.2).
Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains. Zhang, D., Raasi, S., Fushman, D. (2008) J Mol Biol 377: 162-180 PMID: 18241885 DOI: 10.1016/j.jmb.2007.12.029
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{{Information |Description=NMR structure of ubiquitin (orange) in complex with the ubiquitin-associated (UBA) domain of ubiquilin-1 (blue). All 10 models of the NMR ensemble are shown. Isoleucine 44, the center of a hydrophobic patch on the ubiquitin surface, is shown in blue, highlighting its role in interactions with the UBA domain. Rendered from PDB ID 2JY6 using Pymol (open source version 2.2). |Source={{own}} |Date=19 December 2020 |Author= Opabinia regalis |Per...