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Summary
| Description |
English: Branaplam acts to promote exon 7 inclusion in SMA patients by enhancing splicing at the exon 7-exon 8 junction. The small molecule (NVS-SM2) enhances recognition of SMN2 transcripts by U1-U2 specifically by enhancing the affinity of U1 to the 5'-splice site of SMN exon 7. Adapted from Palacino, J. et al. Nature Chemical Biology 2015, 11, 511. |
| Date | |
| Source | Own work |
| Author | Curet115 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:43, 1 March 2018 | | 462 × 570 (97 KB) | Curet115 | Cross-wiki upload from en.wikipedia.org |
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