DescriptionDNA DSB TOP2B PARP-1 complex with NHEJ enzymes.jpg
English: Paused RNA polymerase and limited short-term TOP2B-induced DNA double-strand break. The 5' ends of DNA are covalently joined to tyrosine within the TOP2B dimer complexed with PARP-1. The NHEJ repair pathway components DNA-PKcs, KU70/KU80 and DNA LIGASE IV are also associated with the TOP2B dimer-PARP-1 complex.
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