English: The dotted boxes indicate the four different generations of genome annotators and their most representative characteristics. First generation (blue) where annotators used ab initio methods at a local scale, second generation (red) with genome-wide ab initio methods, third generation (green) characterized by a combination of ab initio methods and homology-based annotations, and the fourth generation (orange) in which an approach to identification of the non-coding regions of DNA and study at the population level represented by the pangenome begun.