English: In the left panel, molecular interactions involved in murburn concept are shown. A murzyme may use (generate/modulate/stabilize/utilize) DRS, which may enter into interactive equilibriums with diverse or select molecules and ions in milieu, giving rise to catalytic electron or moiety transfers, including posttranslational modifications (PTMs) of auto or hetero proteins. The central panel shows the overall systemic or macroscopic physiological overview of ECS-initiated murburn in cells leading to their functioning as SCEs. Methane (CH4) is considered as an example of nutrient input. One of its murburn products (CO2) is a voidable gas and the other product (water, H2O) is also the solvent. Owing to colligative effects, the latter is spontaneously mobilized to move out, thereby retaining cellular composition in a dynamic fashion. Physically, these processes also generate heat and turgor. Chemically, the transient DRS enable electrical activity, power otherwise non-spontaneous reactions and enable seamless coherence. The conceptual importance of murburn concept as a founding principle of life is shown in the right panel. While the vitally deterministic central dogma allows for topology/affinity based selectivity, the inevitable stochastic (based in chanced events) murburn processes complement with other parameters needed to support life.