File talk:Lorcaserin vs dexfenfluramine.svg

Latest comment: 12 years ago by Edgar181

I don't think this image is accurate. The molecule depicted in the image for comparison is not the correct optical isomer for Dexfenfluramine. It's a possible optical isomer of Dexfenfluramine, but it's not the actual molecule itself. The molecular geometry isn't correct. Two bonds are rotated, in opposite directions relative to one another, to make the molecule portrayed as Dexfenfluramine appear more like that of Lorcaserin. Since this particular optical isomer has never been proven to be a product of Dexfenfluramine synthesis, it's an inaccurate comparison between the two. 108.77.64.46 (talk) 21:42, 10 May 2012 (UTC)Reply

The structure of dexfenfluramine depicted in this image appears to be correct to me. It is the (S)-enantiomer, just as is shown at dexfenfluramine in File:Dexfenfluramine.svg. It is shown in a different conformation, but the molecular geometry is flexible enough to access this conformation. It is not unusual for pharmacological agents to adopt different conformations such as this in order to bind to a molecular target. -- Ed (Edgar181) 17:09, 11 May 2012 (UTC)Reply