First window may refer to:
- first broadcast syndication rights for a work
- the post-grant review period for third-party challenge and opposition of a pending patent or trademark
- a wavelength band or transmission window in fibre-optic communications
- the initial 4-6 hour period of ischemic preconditioning, known as classical or early preconditioning, in which a coronary occlusion can limit injuries of a subsequent ischaemia reperfusion in the myocardium