Five Mile Creek is an Australian television series.
Five Mile Creek or Fivemile Creek may also refer to:
- Fivemile Creek (Altamaha River tributary), a stream in Georgia
- Fivemile Creek (Spring River), a stream in Missouri and Oklahoma
- Fivemile Creek (Youngs Creek), a stream in Missouri
- Fivemile Creek (Susquehanna River), a stream in New York
- Fivemile Creek (East Branch Oil Creek tributary), a stream in Crawford County, Pennsylvania
- Fivemile Creek (Wood County, Wisconsin), a stream in Wood and Portage counties, Wisconsin