Fram 2 may refer to:
- Fram2, a crewed Earth-polar-orbit space mission aboard a SpaceX Dragon2 Crew Dragon, planned for 2025, the first ever manned polar space mission
- IF Fram 2 (Idrettsforeningen Fram 2), the "2. divisjon" reserve soccer team for 'IF (Sports Association) Fram 1' (Fram Larvik), a Norwegian soccer club in Larvik
- FRAM-2, a mounting position on the International Space Station for storage on the external stowage platform
- FRAM II, U.S. Navy Fleet Rehabilitation and Modernization 2 program