Francisco Reyes may refer to:
- Francisco Reyes (equestrian), Argentine equestrian
- Francisco Reyes Morandé, Chilean actor
- Francisco Reyes (colonial-era Filipino banker)
- Francisco Reyes (illustrator), Filipino illustrator
- Francisco Reyes (footballer, born 1990), Honduran football goalkeeper
- Francisco Reyes (footballer, born 1941) (1941-76), Paraguayan football midfielder