Francisco de Borja Álvarez de Toledo y Gonzaga, 12th Marquis of Villafranca (9 June 1763 – 12 February 1821) inherited the title of Marquis of Villafranca from his elder brother José Álvarez de Toledo, Duke of Alba in 1796, as well as 14th Marquis of Cazaza , 12th Duke of Bivona and 12th Marquis of Los Vélez .
Portrait of the 12th Marquess of Villafranca, c. 1800
He was married in Madrid, on 28 January 1798, to María Tomasa Palafox y Portocarrero (1780–1835), the daughter of Felipe Antonio de Palafox Croy and Maria Francisca de Sales de Guzmán, Grandee of Spain and Condesa de Montijo, (1763–1821). They had six children, two girls and four boys, the eldest boy, Francisco, dying aged 16. Álvarez was succeeded by his second son, Pedro (1803–1867).
Ancestors of Francisco de Borja Álvarez de Toledo, 12th Marquis of Villafranca 16. Fadrique de Toledo Osorio, 7th Marquis of Villafranca 8. José Fadrique de Toledo Osorio, 8th Marquis of Villafranca 17. María Manuela Fernández de Córdoba y Pimentel 4. Fadrique Vicente de Toledo Osorio, 9th Marquis of Villafranca 18. Fernando Moncada de Aragón, 8th Duke of Montalto 9. Catalina Moncada de Aragón, 9th Duchess of Montalto 19. María Teresa Fajardo, 6th Marquise of los Vélez 2. Antonio Álvarez de Toledo, 10th Marquis of Villafranca 20. Juan Claros Pérez de Guzmán, 11th Duke of Medina Sidonia 10. Manuel Pérez de Guzmán, 12th Duke of Medina Sidonia 21. María Teresa Pimentel y Benavides 5. Juana Pérez de Guzmán y Silva 22. Gregorio de Silva, 9th Duke of the Infantado 11. Luisa María de Silva y Haro 23. María de Haro y Fernández de Córdoba 1. Francisco de Borja Álvarez de Toledo, 12th Marquis of Villafranca 24. Carlo Gonzaga, 2nd Prince of Castiglione 12. Ferdinando Gonzaga, 3rd Prince of Castiglione 25. Isabella Lelio Martinengo 6. Francesco Gonzaga, 1st Duke of Solferino 26. Alexander II Pico, Duke of Mirandola 13. Princess Laura Picco della Mirandola 27. Princess Anna Beatrice d'Este of Modena 3. Princess Maria Antonia Gonzaga 28. Marino Caracciolo, 4th Prince of Santo Buono 14. Carmine Caracciolo, 5th Prince of Santo Buono 29. Giovanna Caracciolo di Torella 7. Giulia Caracciolo di Santo Buono 30. Francesco Ruffo, 4th Duke of Bagnara 15. Giovanna Ruffo di Bagnara 31. Giovanna Lanza