Frank Little may refer to:
- Frank Little (unionist) (1879–1917), American IWW labor leader
- Sir Frank Little (bishop) (1925–2008), Australian Roman Catholic archbishop
- Frank Little (tenor) (1939–2006), operatic tenor
- Frank Little, one of The Littles, fictional characters from the series of children's novels by John Peterson
- Frank Little (sport shooter) (1936–1993), American Olympic shooter
See also
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