The name Frederick William usually refers to several monarchs and princes of the Hohenzollern dynasty:
- Frederick William, Elector of Brandenburg (1620–1688)
- Frederick William, Duke of Mecklenburg-Schwerin (1675–1713)
- Frederick William I of Prussia (1688–1740), King of Prussia
- Frederick William II of Prussia (1744–1797), King of Prussia
- Frederick William III of Prussia (1770–1840), King of Prussia
- Frederick William IV of Prussia (1795–1861), King of Prussia
- Frederick William, Grand Duke of Mecklenburg-Strelitz (1819–1904)
- Frederick III, German Emperor (1831–1888), German Emperor and King of Prussia. He was known as Frederick William when he was Crown Prince.
- Prince Friedrich Wilhelm of Prussia (1880–1925), son of Prince Albert of Prussia and great-grandson of Frederick William III.
Other nobility with the name Frederick William are:
- Frederick William von Steuben (1730–1794), Prussian officer in the American Revolutionary War
- Frederick William von Hessenstein (1735–1808), Swedish statesman and soldier
- Frederick William Hervey, 1st Marquess of Bristol (1769–1859)
- Frederick William, Duke of Brunswick and Lüneburg (1771–1815)
- Frederick William Pethick-Lawrence, 1st Baron Pethick-Lawrence (1871–1961)
- Frederick William Mulley (1918–1995), British politician and economist
- Prince Frederick of Great Britain (1750–1765), son of Frederick, Prince of Wales
Other uses:
- Frederick William University (Friedrich-Wilhelms-Universität), a predecessor to the Humboldt University of Berlin
- Mount Frederick William, Jervis Inlet region, British Columbia, Canada