Gem-associated protein 6

GEMIN6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y96
Identifiers
Aliases	GEMIN6, gem nuclear organelle associated protein 6
External IDs	OMIM: 607006; MGI: 1914492; HomoloGene: 11711; GeneCards: GEMIN6; OMA:GEMIN6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	38,785,002 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	80,535,926 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right testis; ; left testis; ; islet of Langerhans; ; oocyte; ; mucosa of transverse colon; ; right adrenal gland; ; bronchial epithelial cell; ; right adrenal cortex; ; right lobe of liver;
	Top expressed in
	epiblast; ; embryo; ; blastocyst; ; morula; ; primary oocyte; ; embryo; ; yolk sac; ; proximal tubule; ; placenta; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; SMN complex; SMN-Sm protein complex; cytosol; nuclear body; nucleus; nucleoplasm; gemini of coiled bodies;
Biological process	mRNA splicing, via spliceosome; mRNA processing; spliceosomal complex assembly; RNA splicing; spliceosomal snRNP assembly; import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	79833
	67242
	ENSG00000152147
	ENSMUSG00000055760
	Q8WXD5
	Q9CX53
	NM_024775
	NM_026053; NM_001355458
	NP_079051
	NP_080329; NP_001342387
	Wikidata
View/Edit Human	View/Edit Mouse

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.^[5]^[6] The gem-associated proteins are those found in the gems of Cajal bodies.

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]^[6]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152147 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055760 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
^ ^a ^b "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152147 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055760 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11748230-5] Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.

[entrez-6] "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid12065586-8] Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

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Gem-associated protein 6

Contents

Function

Interactions

References

Further reading