GGA3

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.

GGA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Identifiers
Aliases	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
External IDs	OMIM: 606006; MGI: 2384159; HomoloGene: 121703; GeneCards: GGA3; OMA:GGA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 75,236,599 bp End 75,262,363 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 115,475,081 bp End 115,494,877 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte pylorus gastric mucosa spleen monocyte nipple lymph node upper lobe of left lung fundus Top expressed in zygote secondary oocyte neural layer of retina tail of embryo primary visual cortex superior frontal gyrus cerebellar cortex yolk sac facial motor nucleus genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin binding Cellular component endosome trans-Golgi network endosome membrane intracellular anatomical structure membrane clathrin adaptor complex Golgi apparatus early endosome membrane recycling endosome membrane early endosome recycling endosome Biological process protein transport intracellular protein transport positive regulation of protein catabolic process vesicle-mediated transport protein localization to lysosome regulation of protein stability protein destabilization endocytic recycling protein localization to cell surface Golgi to plasma membrane protein transport negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23163 260302 Ensembl ENSG00000125447 ENSMUSG00000020740 UniProt Q9NZ52 Q8BMI3 RefSeq (mRNA) NM_001172703 NM_001172704 NM_001291641 NM_001291642 NM_014001 NM_138619 NM_001252067 NM_173048 RefSeq (protein) NP_001166174 NP_001166175 NP_001278570 NP_001278571 NP_054720 NP_619525 NP_001238996 NP_766636 Location (UCSC) Chr 17: 75.24 – 75.26 Mb Chr 11: 115.48 – 115.49 Mb PubMed search
Wikidata
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This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.

Interactions

GGA3 has been shown to interact with ARF1 and ARF3.

Further reading

• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (April 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
• Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
• Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
• Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (June 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
• Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH (February 2002). "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature. 415 (6874): 933–7. Bibcode:2002Natur.415..933M. doi:10.1038/415933a. PMID 11859375. S2CID 4430757.
• Takatsu H, Yoshino K, Toda K, Nakayama K (July 2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". The Biochemical Journal. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
• Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS (July 2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology. 9 (7): 532–6. doi:10.1038/nsb807. PMID 12032548. S2CID 23740463.
• Doray B, Bruns K, Ghosh P, Kornfeld SA (June 2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
• Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
• Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (September 2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science. 297 (5587): 1700–3. Bibcode:2002Sci...297.1700D. doi:10.1126/science.1075327. PMID 12215646. S2CID 8810528.
• Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
• Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
• Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y (July 2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications. 306 (3): 687–92. doi:10.1016/S0006-291X(03)01032-5. PMID 12810073.
• He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (October 2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry. 42 (42): 12174–80. doi:10.1021/bi035199h. PMID 14567678.
• Ghosh P, Griffith J, Geuze HJ, Kornfeld S (November 2003). "Mammalian GGAs act together to sort mannose 6-phosphate receptors". The Journal of Cell Biology. 163 (4): 755–66. doi:10.1083/jcb.200308038. PMC 2173681. PMID 14638859.
• Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K (February 2004). "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". The Journal of Biological Chemistry. 279 (8): 7105–11. doi:10.1074/jbc.M311702200. PMID 14660606.