GPHB5

Glycoprotein hormone beta-5 is a protein that in humans is encoded by the GPHB5 gene.

GPHB5
Identifiers
Aliases	GPHB5, B5, GPB5, ZLUT1, glycoprotein hormone beta 5, glycoprotein hormone subunit beta 5
External IDs	OMIM: 609652; MGI: 2156540; HomoloGene: 18476; GeneCards: GPHB5; OMA:GPHB5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q23.2 Start 63,312,835 bp End 63,318,935 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 75,458,496 bp End 75,463,555 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right hemisphere of cerebellum thigh muscle of thigh prefrontal cortex Brodmann area 9 lymph node hypothalamus right frontal lobe nucleus accumbens Top expressed in embryo primary oocyte zygote neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity thyrotropin-releasing hormone receptor binding protein heterodimerization activity protein binding Cellular component extracellular region extracellular space cytoplasm Biological process regulation of thyroid hormone mediated signaling pathway cell-cell signaling hormone-mediated signaling pathway cell surface receptor signaling pathway regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122876 217674 Ensembl ENSG00000179600 ENSMUSG00000048982 UniProt Q86YW7 Q812B2 RefSeq (mRNA) NM_145171 NM_175644 RefSeq (protein) NP_660154 NP_783575 Location (UCSC) Chr 14: 63.31 – 63.32 Mb Chr 12: 75.46 – 75.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM]

References

Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#

Further reading

• Okada SL, Ellsworth JL, Durnam DM, et al. (2006). "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor". Mol. Endocrinol. 20 (2): 414–25. doi:10.1210/me.2005-0270. PMID 16210345.
• Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/mend.16.7.0871. PMID 12089349.
• Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.