Galectin-2

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.

LGALS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HLC
Identifiers
Aliases	LGALS2, HL14, galectin 2
External IDs	OMIM: 150571; MGI: 895068; HomoloGene: 4741; GeneCards: LGALS2; OMA:LGALS2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 37,570,248 bp End 37,582,616 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 78,735,060 bp End 78,739,729 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder monocyte pancreatic ductal cell rectum granulocyte mucosa of transverse colon human kidney body of pancreas mucosa of ileum mucosa of sigmoid colon Top expressed in gastric mucosa epithelium of stomach mucous cell of stomach crypt of lieberkuhn of small intestine pyloric antrum duodenum migratory enteric neural crest cell ileum intestinal epithelium epithelium of small intestine More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 3957 107753 Ensembl ENSG00000100079 ENSMUSG00000043501 UniProt P05162 Q9CQW5 RefSeq (mRNA) NM_006498 NM_025622 RefSeq (protein) NP_006489 NP_079898 Location (UCSC) Chr 22: 37.57 – 37.58 Mb Chr 15: 78.74 – 78.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to Lymphotoxin alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.

Further reading

• Gitt MA, Massa SM, Leffler H, Barondes SH (1992). "Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin". J. Biol. Chem. 267 (15): 10601–6. doi:10.1016/S0021-9258(19)50059-X. PMID 1375225.
• Gitt MA, Barondes SH (1986). "Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7603–7. Bibcode:1986PNAS...83.7603G. doi:10.1073/pnas.83.20.7603. PMC 386769. PMID 3020551.
• Lobsanov YD, Gitt MA, Leffler H, et al. (1994). "X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution". J. Biol. Chem. 268 (36): 27034–8. doi:10.2210/pdb1hlc/pdb. PMID 8262940. S2CID 44347534.
• Lobsanov YD, Gitt MA, Leffler H, et al. (1993). "Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II)". J. Mol. Biol. 233 (3): 553–5. doi:10.1006/jmbi.1993.1533. PMID 8411163.
• Mehrabian M, Gitt MA, Sparkes RS, et al. (1993). "Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13". Genomics. 15 (2): 418–20. doi:10.1006/geno.1993.1078. PMID 8449510.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ozaki K, Inoue K, Sato H, et al. (2004). "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro". Nature. 429 (6987): 72–5. Bibcode:2004Natur.429...72O. doi:10.1038/nature02502. PMID 15129282.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Christensen MB, Lawlor DA, Gaunt TR, et al. (2006). "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study". Diabetologia. 49 (4): 673–7. doi:10.1007/s00125-006-0145-3. PMID 16468038.
• Stowell SR, Karmakar S, Stowell CJ, et al. (2007). "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells". Blood. 109 (1): 219–27. doi:10.1182/blood-2006-03-007153. PMC 1785076. PMID 16940423.
• Mangino M, Braund P, Singh R, et al. (2007). "LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians". Atherosclerosis. 194 (1): 112–5. doi:10.1016/j.atherosclerosis.2006.10.004. PMID 17098239.
• Kimura A, Takahashi M, Choi BY, et al. (2007). "Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations". Tissue Antigens. 69 (3): 265–9. doi:10.1111/j.1399-0039.2006.00798.x. PMID 17493152.