Glafenine

Glafenine
Clinical data
ATC code	N02BG03 (WHO) ;
Identifiers
	IUPAC name 2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate;
CAS Number	3820-67-5;
PubChem CID	3474;
ChemSpider	3355;
UNII	46HL4I09AH;
ChEBI	CHEBI:31653 ;
ChEMBL	ChEMBL146095;
CompTox Dashboard (EPA)	DTXSID1048546 ;
ECHA InfoCard	100.021.197
Chemical and physical data
Formula	C19H17ClN2O4
Molar mass	372.81 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	169 to 170 °C (336 to 338 °F)
	SMILES O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2;
	InChI InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22); Key:GWOFUCIGLDBNKM-UHFFFAOYSA-N;

Glafenine is a nonsteroidal anti-inflammatory drug (NSAID). Use of glafenine is limited due to the risk of anaphylaxis and acute kidney failure.^[1]^[2]

References

^ "Withdrawal of glafenine". The Lancet. 339 (8789): 357. 1992. doi:10.1016/0140-6736(92)91670-4. S2CID 54255503.
^ Kleinknecht D, Landais P, Goldfarb B (June 1986). "Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study". Clinical Nephrology. 25 (6): 275–81. PMID 2873910.

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Clinical data

ATC code	N02BG03 (WHO)
Identifiers
IUPAC name 2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate
CAS Number	3820-67-5
PubChem CID	3474
ChemSpider	3355
UNII	46HL4I09AH
ChEBI	CHEBI:31653^Y
ChEMBL	ChEMBL146095
CompTox Dashboard (EPA)	DTXSID1048546
ECHA InfoCard	100.021.197
Chemical and physical data
Formula	C₁₉H₁₇ClN₂O₄
Molar mass	372.81 g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	169 to 170 °C (336 to 338 °F)
SMILES O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2
InChI InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22) Key:GWOFUCIGLDBNKM-UHFFFAOYSA-N