Glassy cell carcinoma of the cervix

Glassy cell carcinoma of the cervix
Glassy cell carcinoma of the cervix
Other names	Glassy cell carcinoma
	Micrograph of a glassy cell carcinoma of the cervix. H&E stain.
Specialty	Oncology

Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix.^[1] The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.

Signs and symptoms

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.^{[citation needed]}

Cause

Diagnosis

The diagnosis is based on tissue examination, e.g. biopsy.^{[citation needed]}

Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining highlights the plasma membrane.^[2]

Treatment

The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.^[2]

Additional images

Low mag.
High mag.

References

^ Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix". Journal of Obstetrics and Gynaecology Research. 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406. S2CID 23501330.
^ ^a ^b Deshpande, AH.; Kotwal, MN.; Bobhate, SK. (2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". Indian J Cancer. 41 (2): 92–5. doi:10.4103/0019-509X.12353. hdl:1807/2939. PMID 15318016. S2CID 8377065.

External links

[pmid19527406-1] Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix". Journal of Obstetrics and Gynaecology Research. 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406. S2CID 23501330.

[pmid15318016-2] Deshpande, AH.; Kotwal, MN.; Bobhate, SK. (2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". Indian J Cancer. 41 (2): 92–5. doi:10.4103/0019-509X.12353. hdl:1807/2939. PMID 15318016. S2CID 8377065.

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