Initiation-specific alpha-1,6-mannosyltransferase
In enzymology, an initiation-specific alpha-1,6-mannosyltransferase (EC 2.4.1.232) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being linked by an alpha-1,6-D-mannosyl-D-mannose bond.
| Initiation-specific alpha-1,6-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.232 | ||||||||
| CAS no. | 346003-17-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase. Other names in common use include alpha-1,6-mannosyltransferase, GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase, GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase, and glycolipid 6-alpha-mannosyltransferase. This enzyme participates in high-mannose type n-glycan biosynthesis.
References
edit- Romero PA, Herscovics A (1989). "Glycoprotein biosynthesis in Saccharomyces cerevisiae Characterization of alpha-1,6-mannosyltransferase which initiates outer chain formation". J. Biol. Chem. 264 (4): 1946–50. doi:10.1016/S0021-9258(18)94125-6. PMID 2644248.
- Reason AJ, Dell A, Romero PA, Herscovics A (1991). "Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae". Glycobiology. 1 (4): 387–91. doi:10.1093/glycob/1.4.387. PMID 1820199.
- Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y (1993). "Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae". J. Biol. Chem. 268 (35): 26338–45. doi:10.1016/S0021-9258(19)74320-8. PMID 8253757.
- Yamamoto K, Okamoto M, Yoko-o T, Jigami Y (2003). "Salt stress induces the expression of Schizosaccharomyces pombe och1+, which encodes an initiation-specific alpha-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins". Biosci. Biotechnol. Biochem. 67 (4): 927–9. doi:10.1271/bbb.67.927. PMID 12784644.
- Cui Z, Horecka J, Jigami Y (2002). "Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae". Yeast. 19 (1): 69–77. doi:10.1002/yea.801. PMID 11754484. S2CID 36308897.
- Tsukahara K, Watanabe T, Yoko-o T, Chigami Y (2001). "Schizosaccharomyces pombe och1+ gene encoding alpha-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation". Jpn. Kokai Tokkyo Koho. Koho: 11.
- Nakayama K, Nakanishi-Shindo Y, Tanaka A, Haga-Toda Y, Jigami Y (1997). "Substrate specificity of alpha-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae". FEBS Lett. 412 (3): 547–50. doi:10.1016/S0014-5793(97)00634-0. PMID 9276464.
- H, Kobayashi H, Suzuki S, Okawa Y (1996). "Characterization of alpha-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan". Eur. J. Biochem. 240 (1): 37–44. doi:10.1111/j.1432-1033.1996.0037h.x. PMID 8797833.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - MacKay VL; Welch, SK; Klebl, F; Gilbert, T; Seidel, P; Grant, FJ; O'Hara, PJ; MacKay, VL (1994). "Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2723–7. Bibcode:1994PNAS...91.2723Y. doi:10.1073/pnas.91.7.2723. PMC 43442. PMID 8146181.
