Diprophylline

Diprophylline
Clinical data
Trade names	Lufyllin
Other names	7-(2,3-Dihydroxy-propyl)theophylline
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682494
Routes of; administration	By mouth
ATC code	R03DA01 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name 7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;
CAS Number	479-18-5 ;
PubChem CID	3182;
IUPHAR/BPS	7070;
DrugBank	DB00651 ;
ChemSpider	3070 ;
UNII	263T0E9RR9;
KEGG	D00691 ;
ChEBI	CHEBI:4728 ;
ChEMBL	ChEMBL1752 ;
CompTox Dashboard (EPA)	DTXSID6022975 ;
ECHA InfoCard	100.006.843
Chemical and physical data
Formula	C10H14N4O4
Molar mass	254.246 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ncn(c1C(=O)N2C)CC(O)CO)C;
	InChI InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 ; Key:KSCFJBIXMNOVSH-UHFFFAOYSA-N ;
	(verify)

Diprophylline (INN)^[1] or dyphylline (USAN) (trade names Dilor, Lufyllin) is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.^[2]^[3]

References

^ "International Non-Proprietary Names. Recommended International Non-Proprietary Names (Rec. I.N.N.): List 1" (PDF). World Health Organization. 1955. p. 188.
^ Schwabe U, Ukena D, Lohse MJ (September 1985). "Xanthine derivatives as antagonists at A1 and A2 adenosine receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 330 (3): 212–21. doi:10.1007/bf00572436. PMID 2997628. S2CID 12190457.
^ Iancu L, Shneur A, Cohen H (1979). "Trials with xanthine derivatives in systemic treatment of psoriasis". Dermatologica. 159 (1): 55–61. doi:10.1159/000250562. PMID 225216.

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