Guadagni is a surname. Notable people with the surname include:
- Bernardo Guadagni (1361–1434), Gonfalonier of Justice
- Gaetano Guadagni (1728–1792), Italian mezzo-soprano castrato singer
- Giovanni Antonio Guadagni (1674–1759), Italian Roman Catholic cardinal
- Nicky Guadagni (born 1952), Canadian actress
See also
edit- Guadagnino, surname
- Guadagno, surname
- Palazzo Guadagni Strozzi Sacrati, palace in Tuscany