Guillermo Vázquez may refer to:
- Guillermo Vázquez (footballer) (born 1967), Mexican footballer and manager
- Guillermo Vázquez (chess player) (born 1997), Paraguayan chess player
- Guillermo Vásquez (politician) (born 1942), Chilean politician
- Guillermo Vasquez (1953–1996), American gay rights, AIDS, and Latino community activist, namesake of Guillermo Vasquez Corner