Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene .[ 5] [ 6] [ 7]
H2BC21 Identifiers Aliases H2BC21 , GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, histone cluster 2, H2be, histone cluster 2 H2B family member e, H2B clustered histone 21, HIST2H2BE, H2BE, H2B-GL105External IDs OMIM : 601831 ; MGI : 2448409 ; HomoloGene : 128426 ; GeneCards : H2BC21 ; OMA :H2BC21 - orthologs Wikidata
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000184678 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069308 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 .
^ a b "Entrez Gene: HIST2H2BE histone cluster 2, H2be" .
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Overview of all the structural information available in the PDB for UniProt : Q16778 (Histone H2B type 2-E) at the PDBe-KB .