HEPPS (buffer)

HEPPS
Names
	Preferred IUPAC name 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
	Other names HEPPS, EPPS
Identifiers
CAS Number	16052-06-5;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:42298 ;
ChemSpider	76886 ;
ECHA InfoCard	100.036.528
PubChem CID	85255;
UNII	8JN5PQW99C ;
CompTox Dashboard (EPA)	DTXSID3066003 ;
	InChI InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N ; InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYAP;
	SMILES O=S(=O)(O)CCCN1CCN(CCO)CC1;
Properties
Chemical formula	C9H20N2O4S
Molar mass	252.33 g·mol−1
Melting point	(decomposes)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.^[1]

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.^[2]^[3]^[4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.^[5]^[6]^[7]

References

^ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.
^ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.
^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. Bibcode:2015NatCo...6.8997K. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
^ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.
^ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4): eaav1388. Bibcode:2019SciA....5.1388K. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMC 6469948. PMID 31001580.
^ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined". Analysis & Separations from Technology Networks. Retrieved 2019-09-30.
^ "A possible blood test for early-stage Alzheimer's disease". medicalxpress.com. Retrieved 2019-09-30.

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[1] Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.

[2] "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.

[3] Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. Bibcode:2015NatCo...6.8997K. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.

[4] "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.

[5] Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4): eaav1388. Bibcode:2019SciA....5.1388K. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMC 6469948. PMID 31001580.

[6] "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined". Analysis & Separations from Technology Networks. Retrieved 2019-09-30.

[7] "A possible blood test for early-stage Alzheimer's disease". medicalxpress.com. Retrieved 2019-09-30.

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HEPPS (buffer)

See also

References