Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BC gene .[ 5] [ 6] [ 7]
H2BC4 Identifiers Aliases H2BC4 External IDs OMIM : 602847 ; MGI : 2448386 ; HomoloGene : 136774 ; GeneCards : H2BC4 ; OMA :H2BC4 - orthologs Wikidata
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000180596 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058385 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics . 40 (2): 314–22. doi :10.1006/geno.1996.4592 . PMID 9119399 . ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b "Entrez Gene: HIST1H2BC histone cluster 1, H2bc" .
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PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H2B type 1-C
