Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene.[5]

MNX1
Identifiers
AliasesMNX1, HB9, HLXB9, HOXHB9, SCRA1, motor neuron and pancreas homeobox 1
External IDsOMIM: 142994; MGI: 109160; HomoloGene: 21137; GeneCards: MNX1; OMA:MNX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005515
NM_001165255

NM_019944

RefSeq (protein)

NP_001158727
NP_005506

NP_064328

Location (UCSC)Chr 7: 156.99 – 157.01 MbChr 5: 29.68 – 29.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

edit

Mutations in the MNX1 gene are associated with Currarino syndrome.[6] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130675Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001566Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HLXB9 homeobox HB9".
  6. ^ Merello E, De Marco P, Ravegnani M, Riccipetitoni G, Cama A, Capra V (2013). "Novel MNX1 mutations and clinical analysis of familial and sporadic Currarino cases". Eur J Med Genet. 56 (12): 648–54. doi:10.1016/j.ejmg.2013.09.011. PMID 24095820.
  7. ^ Zhang, W., Huang, L., Lu, X., Wang, K., Ning, X., & Liu, Z. (2019). Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. Bosnian journal of basic medical sciences, 19(2), 164–171. https://doi.org/10.17305/bjbms.2019.3713

Further reading

edit
edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.