Hefner or Heffner is a German surname meaning 'potter'. It may refer to:
- Hefner (band), British rock band
People with the surname Hefner
edit- Art Hefner (1913–1988), American center fielder
- Avraham Heffner, (1935–2014), Israeli filmmaker
- Berniece Heffner (1897/1898–1989), American labor unionist
- Bill Hefner (1930–2009), US representative from North Carolina
- Bob Heffner (born 1938), Major League Baseball pitcher
- Bryon Hefner, estranged husband of Stan Rosenberg, subject of a sexual harassment scandal
- Christie Hefner (born 1952), former chairman of Playboy Enterprises, daughter of Hugh Hefner
- Cooper Hefner (born 1991), American businessman, son of Hugh Hefner
- Cole Hefner (born 1980), American politician
- Crystal Hefner (born 1986), third wife of Hugh Hefner
- Don Heffner (1911–1989), American second-baseman
- Ellyn Hefner, American politician
- George E. Heffner (1923–2008), American politician
- Hugh Hefner (1926–2017), founder of Playboy magazine
- James A. Hefner (1941–2015), president of Tennessee State University
- Jeremy Hefner (born 1986), MLB pitcher for the New York Mets
- Jerry Hefner (1949–2017), American politician
- J. R. Heffner (born 1972), NASCAR driver
- Keith Hefner, founder and executive director of Youth Communication, a nonprofit organization
- Kyle T. Heffner (born 1957), American actor
- Larry Hefner (born 1949), American linebacker
- Lulu M. Hefner (1874–1954), Cherokee businesswoman
- Philip Hefner (born 1932), Lutheran professor of the theology of evolution
- Ray Heffner (1925–2012), president of Brown University
- Richard Heffner (1925–2013), TV talk show host, and professor at Rutgers Institute
- Robert A. Hefner (1874–1971), Oilman, Oklahoma Hall of Fame 1949, OK Supreme Court Justice and Mayor of Oklahoma City
- Robert A. Hefner, Jr. (1907–1987), Oilman, Oklahoma Hall of Fame 1979 and Golden Gloves Boxer
- Rodrigo Heffner (born 1982), Brazilian footballer