Henle can refer to:
- Friedrich Gustav Jakob Henle, a German physician, pathologist and anatomist (1809–1885)
- Loop of Henle in the kidney, named after Henle
- Fritz Henle, a photographer, known as "Mr. Rollei" for his use of the 2.25" square format film used in the Rolleiflex camera
- Günter Henle, German politician and music publisher
- G. Henle Verlag, German music publishing house
- Moritz Henle, a German composer
- Robert A. Henle, an American electrical engineer
- Robert J. Henle, the 46th President of Georgetown University