High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.197), uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase, acetylglucosamine-oligosaccharide acetylglucosaminyltransferase, UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide 4-beta-N-acetylglucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase
Identifiers
EC no.2.4.1.197
CAS no.123425-54-7
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NCBIproteins
Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-(1->6) to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum

The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links.

References

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  1. ^ Sharkey DJ, Kornfeld R (June 1989). "Identification of an N-acetylglucosaminyltransferase in Dictyostelium discoideum that transfers an "intersecting" N-acetylglucosamine residue to high mannose oligosaccharides". The Journal of Biological Chemistry. 264 (18): 10411–9. PMID 2525124.
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