HLA-DPB1

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M
Identifiers
Aliases	HLA-DPB1, DPB1, HLA-DP, HLA-DP1B, HLA-DPB, major histocompatibility complex, class II, DP beta 1
External IDs	OMIM: 142858; HomoloGene: 129927; GeneCards: HLA-DPB1; OMA:HLA-DPB1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,075,990 bp End 33,089,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node appendix monocyte gallbladder spleen upper lobe of left lung right lung duodenum right coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi network membrane endoplasmic reticulum membrane membrane Golgi membrane plasma membrane transport vesicle membrane MHC class II protein complex cell surface lysosomal membrane endoplasmic reticulum ER to Golgi transport vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane Biological process antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II interferon-gamma-mediated signaling pathway immune system process T cell costimulation positive regulation of interferon-gamma production antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of T cell activation positive regulation of T cell proliferation immune response T cell receptor signaling pathway adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3115 n/a Ensembl ENSG00000236693 ENSG00000230708 ENSG00000229295 ENSG00000226826 ENSG00000215048 ENSG00000223865 ENSG00000230763 ENSG00000237710 n/a UniProt P04440 n/a RefSeq (mRNA) NM_002121 n/a RefSeq (protein) NP_002112 n/a Location (UCSC) Chr 6: 33.08 – 33.09 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

See also

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DP

Further reading

• Mitsunaga S, Kuwata S, Tokunaga K, Uchikawa C, Takahashi K, Akaza T, Mitomi Y, Juji T (1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): 203–11. doi:10.1016/0198-8859(92)90113-2. PMID 1358867.
• Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229–43. doi:10.1111/j.1399-0039.1992.tb02050.x. PMID 1362295.
• Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108–10. doi:10.1111/j.1399-0039.1992.tb01969.x. PMID 1412416.
• Korioth F, Hartung K, Deicher H, Frey J (1992). "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus". Tissue Antigens. 39 (4): 216–9. doi:10.1111/j.1399-0039.1992.tb01938.x. PMID 1529429.
• de Koster HS, Kenter MJ, D'Amaro J, Luiten RM, Schroeijers WE, Giphart MJ, Termijtelen A (1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics. 34 (1): 12–22. doi:10.1007/BF00212307. PMID 1713190. S2CID 21845822.
• Vanderbeeken YE, Duchateau J, Colle H, Gregoire M, Desseilles P, Lucas A (1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes". Arch. Gynecol. Obstet. 248 (4): 199–209. doi:10.1007/BF02390359. PMID 1832848. S2CID 25184115.
• Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
• Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi:10.4049/jimmunol.144.2.526. PMID 1967269.
• Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
• Bugawan TL, Begovich AB, Erlich HA (1990). "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes". Immunogenetics. 32 (4): 231–41. doi:10.1007/BF00187094. PMID 2242906. S2CID 39873046.
• Lair B, Alber C, Yu WY, Watts R, Bahl M, Karr RW (1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. Immunol. 141 (4): 1353–7. doi:10.4049/jimmunol.141.4.1353. PMID 2456351.
• Bugawan TL, Horn GT, Long CM, Mickelson E, Hansen JA, Ferrara GB, Angelini G, Erlich HA (1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". J. Immunol. 141 (11): 4024–30. doi:10.4049/jimmunol.141.11.4024. PMID 2460556.
• Begovich AB, Bugawan TL, Nepom BS, Klitz W, Nepom GT, Erlich HA (1990). "A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9489–93. doi:10.1073/pnas.86.23.9489. PMC 298522. PMID 2512583.
• Scholl P, Diez A, Mourad W, Parsonnet J, Geha RS, Chatila T (1989). "Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4210–4. Bibcode:1989PNAS...86.4210S. doi:10.1073/pnas.86.11.4210. PMC 287420. PMID 2542966.
• Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
• Lee JS, Sartoris S, Briata P, Choi E, Cullen C, Lepaslier D, Yunis I (1989). "Sequence polymorphism of HLA-DP beta chains". Immunogenetics. 29 (5): 346–9. doi:10.1007/BF00352845. PMID 2714855. S2CID 13414587.
• Compagnone-Post P, Turco E, Robinson C, Trucco M (1988). "The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene". Genomics. 2 (1): 8–13. doi:10.1016/0888-7543(88)90103-6. PMID 2838415.
• Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. doi:10.4049/jimmunol.141.11.3715. PMID 2846691.
• Ando A, Inoko H, Kimura M, Ogata S, Tsuji K (1987). "Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains". Hum. Immunol. 17 (3): 355–67. doi:10.1016/0198-8859(86)90286-7. PMID 2878910.
• Kelly A, Trowsdale J (1985). "Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes". Nucleic Acids Res. 13 (5): 1607–21. doi:10.1093/nar/13.5.1607. PMC 341099. PMID 2987832.