Hugh O'Donnell may refer to:
- Hugh O'Donnell (politician) (born 1952), Scottish politician
- Hugh O'Donnell (footballer) (1913–1965), Scottish professional footballer
- Hugh O'Donnell (artist) (born 1950), English painter and printmaker
- Hugh O'Donnell (labor leader) (1869–?), American leader of the Homestead Steel Strike of 1892
- Hugh O'Donnell (priest) (1884–1947), American priest and President of the University of Notre Dame
- Hugh Roe O'Donnell (died 1505), ruler of Tyrconnell
- Hugh Roe O'Donnell (1572–1602), Prince of Tyrconnell
- Sir Hugh O'Donnell (died c. 1600), Irish Gaelic lord
- Hugh Dubh O'Donnell (died 1618), Irish Gaelic lord
- Hugh O'Donnell, 2nd Earl of Tyrconnell (1606–1642), titular King of Tír Conaill
- Hugh Duff O'Donnell (died 1537), leading figure in Gaelic Ireland during the Tudor era