Interleukin 27 receptor, alpha subunit

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.

IL27RA
Identifiers
Aliases	IL27RA, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1, Interleukin 27 receptor, alpha subunit, interleukin 27 receptor subunit alpha
External IDs	OMIM: 605350; MGI: 1355318; HomoloGene: 3562; GeneCards: IL27RA; OMA:IL27RA - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.12 Start 14,031,762 bp End 14,053,218 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C2 Start 84,756,923 bp End 84,769,218 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte lymph node blood appendix spleen apex of heart testicle bone marrow cells upper lobe of left lung Top expressed in Ileal epithelium lymph node mesenteric lymph nodes blood thymus spleen lactiferous gland choroid plexus of fourth ventricle extraocular muscle subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity interleukin-27 receptor activity cytokine receptor activity cytokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane receptor complex Biological process negative regulation of type 2 immune response cell surface receptor signaling pathway positive regulation of interferon-gamma production regulation of isotype switching to IgG isotypes positive regulation of T-helper 1 type immune response immune response defense response to Gram-positive bacterium interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway negative regulation of cellular extravasation negative regulation of T-helper 17 type immune response negative regulation of T cell extravasation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9466 50931 Ensembl ENSG00000104998 ENSG00000288185 ENSMUSG00000005465 UniProt Q6UWB1 O70394 RefSeq (mRNA) NM_004843 NM_016671 RefSeq (protein) NP_004834 NP_057880 Location (UCSC) Chr 19: 14.03 – 14.05 Mb Chr 8: 84.76 – 84.77 Mb PubMed search
Wikidata
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Function

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

Interactions

Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.

Further reading

• Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
• Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature. 407 (6806): 916–20. Bibcode:2000Natur.407..916C. doi:10.1038/35038103. PMID 11057672. S2CID 205009928.
• Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
• Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
• Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". J. Immunol. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Pradhan A, Lambert QT, Reuther GW (2008). "Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18502–7. doi:10.1073/pnas.0702388104. PMC 2141806. PMID 18003935.