ISAM or Isam may refer to:
Computing
editPeople
edit- Isam (name), list of people with the name
- Banu Isam, a former Berber Muslim dynasty
Organizations
edit- Institute for Sales and Account Management
- International Society of Addiction Medicine
- Hitchcock Institute for the Study of American Music at Brooklyn College
- International Society for Aerosols in Medicine
Others
edit- ISAM (album), an album by musician Amon Tobin
- The Iraqi Security Assistance mission, part of the Multi-National Security Transition Command – Iraq