Integrin beta 8

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.

ITGB8
Identifiers
Aliases	ITGB8, integrin subunit beta 8
External IDs	OMIM: 604160; MGI: 1338035; HomoloGene: 18567; GeneCards: ITGB8; OMA:ITGB8 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p21.1 Start 20,330,702 bp End 20,415,754 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 F2 Start 119,121,757 bp End 119,202,537 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium external globus pallidus ventricular zone synovial joint spinal ganglia bronchial epithelial cell corpus epididymis mucosa of paranasal sinus trigeminal ganglion caput epididymis Top expressed in retinal pigment epithelium Epithelium of choroid plexus suprachiasmatic nucleus deep cerebellar nuclei olfactory tubercle sciatic nerve substantia nigra otolith organ utricle medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding extracellular matrix protein binding integrin binding signaling receptor activity Cellular component integrin alphav-beta8 complex integral component of membrane cell surface integrin complex plasma membrane extracellular exosome membrane focal adhesion Biological process integrin-mediated signaling pathway cartilage development placenta blood vessel development cell adhesion ganglioside metabolic process positive regulation of gene expression extracellular matrix organization cell-matrix adhesion negative regulation of gene expression vasculogenesis cell migration cell adhesion mediated by integrin positive regulation of angiogenesis regulation of transforming growth factor beta activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3696 320910 Ensembl ENSG00000105855 ENSMUSG00000025321 UniProt P26012 Q0VBD0 RefSeq (mRNA) NM_002214 NM_177290 RefSeq (protein) NP_002205 NP_796264 Location (UCSC) Chr 7: 20.33 – 20.42 Mb Chr 12: 119.12 – 119.2 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all the variants have been fully characterized. Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.

Clinical significance

High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.

Further reading

• Moyle M, Napier MA, McLean JW (1991). "Cloning and expression of a divergent integrin subunit beta 8". J. Biol. Chem. 266 (29): 19650–8. doi:10.1016/S0021-9258(18)55042-0. PMID 1918072.
• Nishimura SL, Sheppard D, Pytela R (1994). "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain". J. Biol. Chem. 269 (46): 28708–15. doi:10.1016/S0021-9258(19)61963-0. PMID 7525578.
• Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo". Am. J. Physiol. 273 (1 Pt 1): L256–63. doi:10.1152/ajplung.1997.273.1.L256. PMID 9252563.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Cambier S, Mu DZ, O'Connell D, et al. (2001). "A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth". Cancer Res. 60 (24): 7084–93. PMID 11156415.
• Mu D, Cambier S, Fjellbirkeland L, et al. (2002). "The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1". J. Cell Biol. 157 (3): 493–507. doi:10.1083/jcb.200109100. PMC 2173277. PMID 11970960.
• Jarad G, Wang B, Khan S, et al. (2003). "Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis". J. Biol. Chem. 277 (49): 47826–33. doi:10.1074/jbc.M204901200. PMID 12324452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Fjellbirkeland L, Cambier S, Broaddus VC, et al. (2003). "Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue". Am. J. Pathol. 163 (2): 533–42. doi:10.1016/S0002-9440(10)63681-4. PMC 1868219. PMID 12875973.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yan W, Shao R (2006). "Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation". J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.

External links

• ITGB8 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine