ICMT

For the physics institute, see Institute for Condensed Matter Theory.

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.

ICMT
Identifiers
Aliases	ICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase, ICMT protein, human
External IDs	OMIM: 605851; MGI: 1888594; HomoloGene: 5735; GeneCards: ICMT; OMA:ICMT - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.31 Start 6,221,193 bp End 6,235,972 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 152,297,227 bp End 152,307,121 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm stromal cell of endometrium body of tongue olfactory zone of nasal mucosa gastrocnemius muscle islet of Langerhans nasal epithelium right ventricle glutes muscle of thigh Top expressed in neural layer of retina lobe of cerebellum cerebellar vermis spermatocyte lumbar spinal ganglion spermatid retinal pigment epithelium lip dentate gyrus of hippocampal formation granule cell right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity protein C-terminal carboxyl O-methyltransferase activity protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process post-translational protein modification methylation protein targeting to membrane C-terminal protein methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23463 57295 Ensembl ENSG00000116237 ENSMUSG00000039662 UniProt O60725 Q9EQK7 RefSeq (mRNA) NM_012405 NM_170705 NM_133788 RefSeq (protein) NP_036537 NP_598549 Location (UCSC) Chr 1: 6.22 – 6.24 Mb Chr 4: 152.3 – 152.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Further reading

• Choy E, Chiu VK, Silletti J, et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi". Cell. 98 (1): 69–80. doi:10.1016/S0092-8674(00)80607-8. PMID 10412982. S2CID 1018802.
• Lin X, Antalffy B, Kang D, et al. (2000). "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1". Nat. Neurosci. 3 (2): 157–63. doi:10.1038/72101. PMID 10649571. S2CID 2800058.
• Van Dessel GA, De Busser HM, Lagrou AR (2002). "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells". Int. J. Biochem. Cell Biol. 34 (5): 477–86. doi:10.1016/S1357-2725(01)00151-0. PMID 11906819.
• Ahmad M, Zhang Y, Zhang Y, et al. (2002). "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells". Arterioscler. Thromb. Vasc. Biol. 22 (5): 759–64. doi:10.1161/01.ATV.0000015884.61894.DC. PMID 12006387.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kramer K, Harrington EO, Lu Q, et al. (2004). "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis". Mol. Biol. Cell. 14 (3): 848–57. doi:10.1091/mbc.E02-07-0390. PMC 151564. PMID 12631708.
• Winter-Vann AM, Kamen BA, Bergo MO, et al. (2003). "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6529–34. Bibcode:2003PNAS..100.6529W. doi:10.1073/pnas.1135239100. PMC 164480. PMID 12750467.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bergo MO, Gavino BJ, Hong C, et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf". J. Clin. Invest. 113 (4): 539–50. doi:10.1172/JCI18829. PMC 338259. PMID 14966563.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lu Q, Harrington EO, Newton J, et al. (2007). "Inhibition of ICMT induces endothelial cell apoptosis through GRP94". Am. J. Respir. Cell Mol. Biol. 37 (1): 20–30. doi:10.1165/rcmb.2006-0301SM. PMC 1899353. PMID 17347446.