IGFBP1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

IGFBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZT3, 1ZT5, 2DSQ
Identifiers
Aliases	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
External IDs	OMIM: 146730; MGI: 96436; HomoloGene: 498; GeneCards: IGFBP1; OMA:IGFBP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p12.3 Start 45,888,360 bp End 45,893,660 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A1|11 4.75 cM Start 7,147,782 bp End 7,152,546 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua right lobe of liver oocyte secondary oocyte gonad stromal cell of endometrium testicle left ovary right ovary pericardium Top expressed in left lobe of liver right lobe of liver human fetus sexually immature organism embryo yolk sac human kidney right kidney cumulus cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding insulin-like growth factor II binding insulin-like growth factor binding growth factor binding insulin-like growth factor I binding protein binding Cellular component extracellular region Golgi apparatus extracellular space endoplasmic reticulum lumen Biological process PERK-mediated unfolded protein response tissue regeneration insulin receptor signaling pathway regulation of cell growth negative regulation of canonical Wnt signaling pathway signal transduction regulation of insulin-like growth factor receptor signaling pathway positive regulation of cell growth ageing post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3484 16006 Ensembl ENSG00000146678 ENSMUSG00000020429 UniProt P08833 P47876 RefSeq (mRNA) NM_001013029 NM_000596 NM_008341 RefSeq (protein) NP_000587 NP_032367 Location (UCSC) Chr 7: 45.89 – 45.89 Mb Chr 11: 7.15 – 7.15 Mb PubMed search
Wikidata
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Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/edrv.18.6.0321. PMID 9408744.
• Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394. S2CID 2710234.
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. ISBN 9780123646477. PMID 15797461.
• Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7". Genomics. 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120.
• Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12". Genomics. 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735.
• Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1". J. Biol. Chem. 265 (34): 21185–93. doi:10.1016/S0021-9258(17)45344-0. PMID 1701175.
• Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783. S2CID 42755060.
• Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104.
• Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513. S2CID 8083622.
• Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522.
• Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665.
• Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129.
• Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445. S2CID 20571796.
• Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945.
• Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions". J. Biol. Chem. 263 (28): 14203–10. doi:10.1016/S0021-9258(18)68206-7. PMID 2971653.
• Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931.
• Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. Bibcode:1993PNAS...9010553J. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269.
• Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101". J. Biol. Chem. 268 (2): 1125–31. doi:10.1016/S0021-9258(18)54050-3. PMID 7678248.