IL17RA

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.

IL17RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JVF, 4HSA, 4NUX
Identifiers
Aliases	IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A, IMD51
External IDs	OMIM: 605461; MGI: 107399; HomoloGene: 7378; GeneCards: IL17RA; OMA:IL17RA - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.1 Start 17,084,954 bp End 17,115,693 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F1|6 56.95 cM Start 120,440,208 bp End 120,464,520 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte trabecular bone granulocyte bone marrow bone marrow cells tendon of biceps brachii internal globus pallidus mucosa of ileum secondary oocyte Top expressed in granulocyte blood stroma of bone marrow thymus mesenteric lymph nodes aortic valve ascending aorta spleen tibiofemoral joint saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-17 receptor activity signaling receptor binding protein binding Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process positive regulation of cytokine production involved in inflammatory response cell surface receptor signaling pathway fibroblast activation positive regulation of inflammatory response granulocyte chemotaxis positive regulation of interleukin-23 production defense response to fungus cellular response to cytokine stimulus interleukin-17-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23765 16172 Ensembl ENSG00000177663 ENSMUSG00000002897 UniProt Q96F46 Q60943 RefSeq (mRNA) NM_014339 NM_001289905 NM_008359 RefSeq (protein) NP_001276834 NP_055154 NP_032385 Location (UCSC) Chr 22: 17.08 – 17.12 Mb Chr 6: 120.44 – 120.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

See also

• Interleukin-17 receptor

Further reading

• Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine. 9 (11): 794–800. doi:10.1006/cyto.1997.0240. PMID 9367539.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Honorati MC, Meliconi R, Pulsatelli L, et al. (2001). "High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients". Rheumatology (Oxford). 40 (5): 522–7. doi:10.1093/rheumatology/40.5.522. PMID 11371660.
• Footz TK, Brinkman-Mills P, Banting GS, et al. (2001). "Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere". Genome Res. 11 (6): 1053–70. doi:10.1101/gr.154901. PMC 311098. PMID 11381032.
• Haudenschild D, Moseley T, Rose L, Reddi AH (2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer". J. Biol. Chem. 277 (6): 4309–16. doi:10.1074/jbc.M109372200. PMID 11706037.
• Kehlen A, Thiele K, Riemann D, Langner J (2002). "Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis". Clin. Exp. Immunol. 127 (3): 539–46. doi:10.1046/j.1365-2249.2002.01782.x. PMC 1906300. PMID 11966773.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Steiner GE, Newman ME, Paikl D, et al. (2003). "Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate". Prostate. 56 (3): 171–82. doi:10.1002/pros.10238. PMID 12772186. S2CID 34604221.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• McAllister F, Henry A, Kreindler JL, et al. (2005). "Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis". J. Immunol. 175 (1): 404–12. doi:10.4049/jimmunol.175.1.404. PMC 2849297. PMID 15972674.
• Pongcharoen S, Niumsup P, Sanguansermsri D, et al. (2006). "The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells". Am. J. Reprod. Immunol. 55 (4): 291–300. doi:10.1111/j.1600-0897.2006.00366.x. PMID 16533341. S2CID 35458245.
• Toy D, Kugler D, Wolfson M, et al. (2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". J. Immunol. 177 (1): 36–9. doi:10.4049/jimmunol.177.1.36. PMID 16785495.
• Wang X, Dong Z, Zhu DD, Guan B (2006). "Expression profile of immune-associated genes in nasal polyps". Ann. Otol. Rhinol. Laryngol. 115 (6): 450–6. doi:10.1177/000348940611500609. PMID 16805377. S2CID 20528405.
• Rong Z, Cheng L, Ren Y, et al. (2007). "Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6". Cell. Signal. 19 (7): 1514–20. doi:10.1016/j.cellsig.2007.01.025. PMID 17346928.
• Maitra A, Shen F, Hanel W, et al. (2007). "Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7506–11. Bibcode:2007PNAS..104.7506M. doi:10.1073/pnas.0611589104. PMC 1863505. PMID 17456598.

External links

• IL17RA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.