The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.[1][2]
| interleukin 18 receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL18R1 | ||||||
| Alt. symbols | IL1RRP, IL-1Rrp, CD218a | ||||||
| NCBI gene | 8809 | ||||||
| HGNC | 5988 | ||||||
| OMIM | 604494 | ||||||
| RefSeq | NM_003855 | ||||||
| UniProt | Q13478 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q12 | ||||||
| |||||||
| interleukin 18 receptor accessory protein | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL18RAP | ||||||
| Alt. symbols | AcPL, CD218b | ||||||
| NCBI gene | 8807 | ||||||
| HGNC | 5989 | ||||||
| OMIM | 604509 | ||||||
| RefSeq | NM_003853 | ||||||
| UniProt | O95256 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p24.3-24.1 | ||||||
| |||||||
Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.[3]
References
edit- ^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
- ^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
- ^ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.
External links
edit- Receptors,+Interleukin-18 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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