Intravenous leiomyomatosis is a rare condition seen exclusively in women in which leiomyomata, benign smooth muscle tumors, are found in veins. The masses are benign-appearing but can spread throughout the venous system leaving the uterus and even cause death when growing into the heart from the IVC.[1] While the possibility that these arose de novo from the smooth muscle in the blood vessel wall was considered, chromosomal analysis suggests a uterine origin.[2] Intravenous leiomyomata are usually but not always associated with uterine fibroids, and tend to recur.
| Intravenous leiomyomatosis | |
|---|---|
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| Intravenous Leiomyoma |
This condition is related to benign metastasizing leiomyoma, in which the masses appear in more distant locations such as the lung and lymph nodes.[3]
See also
editReferences
edit- ^ Worley Jr, M.; Aelion, A.; Caputo, T.; Kent, K.; Salemi, A.; Krieger, K.; Goldstein, M.; Kuo, D.; Slomovitz, B. (2009). "Intravenous leiomyomatosis with intracardiac extension: a single-institution experience". American Journal of Obstetrics and Gynecology. 201 (6): 574.5e1–5. doi:10.1016/j.ajog.2009.06.037. PMC 4309800. PMID 19729144.
- ^ Dal Cin, P.; Quade, B.; Neskey, D.; Kleinman, M.; Weremowicz, S.; Morton, C. (2003). "Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)". Genes, Chromosomes & Cancer. 36 (2): 205–206. doi:10.1002/gcc.10159. PMID 12508249.
- ^ Patton, K.; Cheng, L.; Papavero, V.; Blum, M.; Yeldandi, A.; Adley, B.; Luan, C.; Diaz, L.; Hui, P.; Yang, X. J. (2006). "Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis". Modern Pathology. 19 (1): 130–140. doi:10.1038/modpathol.3800504. PMID 16357844.