Ioannes II (Greek: Ἰωάννης Β΄, "John II") may refer to:
- Patriarch John II of Constantinople (ruled 518–520)
- John II Komnenos (1087–1143), Byzantine emperor
- John II of Trebizond (c. 1262–1297)
- John II Doukas of Thessaly (ruled 1303–1318)
- John II Orsini (ruled 1323–1335)
See also
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