Jacopo (also Iacopo) is a masculine Italian given name, derivant from Latin Iacōbus. It is an Italian variant of Giacomo (James in English).
- Jacopo Aconcio (c. 1520 – c. 1566), Italian religious reformer
- Jacopo Bassano (c. 1510 – 1592), Italian painter
- Iacopo Barsotti (1921–1987), Italian mathematician
- Jacopo da Bologna (fl. 1340–1360), Italian composer
- Jacopo Comin (1518–1594), Italian painter otherwise known as Tintoretto
- Jacopo Carucci (1494–1557), Italian painter otherwise known as Pontormo
- Jacopo Corsi (1561–1602), Italian composer
- Jacopo da Leona (died 1277), Italian poet
- Jacopo Peri (1561–1633), Italian composer
- Jacopo della Quercia (c. 1374 – 1438), Italian sculptor
- Jacopo Riccati (1676–1754), Italian mathematician
- Jacopo Sadoleto (1477–1547), Italian Catholic cardinal
Fictional characters:
- Jacopo, a key character in the 2002 film version of The Count of Monte Cristo (and a minor character in the book).
- Jacopo Bearzatti, one of the central characters of The House in Fata Morgana and the protagonist of the prequel The House in Fata Morgana: A Requiem for Innocence
- Jacopo Belbo, one of the main characters of Foucault's Pendulum by Umberto Eco
- Jacopo Peterman, a character portrayed by John O'Hurley in the sitcom Seinfeld