James Guy may refer to:
- James Guy (Australian politician) (1860–1921), Australian politician from Tasmania
- James Guy (British politician) (1894–?), Scottish politician, MP for Edinburgh Central 1931–1941
- James Guy (swimmer) (born 1995), British swimmer
- James Lee Guy (born 1968), American actor in film and television in China
This disambiguation page lists articles about people with the same name.
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