Karmageddon may refer to:
- Karmageddon Media, a former Dutch independent record label
- Karmageddon, a periodic event organised by the Join Me movement
- Karmageddon, a 2009 album by Ravi Bissambhar
- "Karmageddon", a song by Soulfly on their self-titled debut album
- "Karmageddon", a song by Hank Williams III on his album Rebel Within
- "Karmageddon", a song by M.I.A. on her album Matangi