Kirs may refer to:
- People
- Eduard Kirs (1887–1963), Estonian music teacher, trade unionist and politician
- Friido Kirs (1889–1948), Estonian schoolteacher and politician
- Rudolf Kirs (1915–1963), Czech cellist
- Urmas Kirs (b. 1966), Estonian footballer and manager
- Vallo Kirs (b. 1987), Estonian actor
- Places
- Kirs, former name of Kitsk, a village in Armenia
- Kirs, Russia, a town in Kirov Oblast, Russia
- Other
- Kirs, inwardly-rectifying potassium channels
- KIRS (FM), a radio station (107.7 FM) licensed to serve Stockton, Missouri, United States
- Kirsch Municipal Airport, ICAO code KIRS