Late endosomal/lysosomal adaptor, mapk and mtor activator 1

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene.

LAMTOR1
Identifiers
Aliases	LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
External IDs	OMIM: 613510; MGI: 1913758; HomoloGene: 9909; GeneCards: LAMTOR1; OMA:LAMTOR1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 72,085,895 bp End 72,103,297 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E2 Start 101,555,111 bp End 101,575,882 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of ileum granulocyte right adrenal cortex left adrenal gland left adrenal cortex stromal cell of endometrium right lobe of thyroid gland C1 segment left lobe of thyroid gland Top expressed in white adipose tissue quadriceps femoris muscle yolk sac lip granulocyte skeletal muscle tissue proximal tubule right kidney muscle of thigh heart More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding molecular adaptor activity GTPase binding Cellular component endosome late endosome membrane membrane Ragulator complex lysosomal membrane membrane raft lysosome extracellular exosome plasma membrane azurophil granule membrane specific granule membrane ficolin-1-rich granule membrane Biological process regulation of cholesterol import regulation of cholesterol efflux endosome organization lysosome localization cellular response to amino acid stimulus cholesterol homeostasis regulation of receptor recycling lysosome organization regulation of cholesterol esterification positive regulation of TOR signaling positive regulation of MAPK cascade neutrophil degranulation regulation of macroautophagy regulation of cell growth regulation of molecular function endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55004 66508 Ensembl ENSG00000149357 ENSMUSG00000030842 UniProt Q6IAA8 Q9CQ22 RefSeq (mRNA) NM_017907 NM_025605 RefSeq (protein) NP_060377 NP_079881 Location (UCSC) Chr 11: 72.09 – 72.1 Mb Chr 7: 101.56 – 101.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M (March 2009). "The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes". EMBO J. 28 (5): 477–89. doi:10.1038/emboj.2008.308. PMC 2657578. PMID 19177150.
• Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M (October 2009). "A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion". J. Biol. Chem. 284 (40): 27315–26. doi:10.1074/jbc.M109.041400. PMC 2785659. PMID 19654316.
• Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (April 2010). "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids". Cell. 141 (2): 290–303. doi:10.1016/j.cell.2010.02.024. PMC 3024592. PMID 20381137.
• Hoshino D, Koshikawa N, Seiki M (January 2011). "A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC". J. Biol. Chem. 286 (4): 3139–48. doi:10.1074/jbc.M110.159715. PMC 3024806. PMID 21087931.
• Malek M, Guillaumot P, Huber AL, Lebeau J, Pétrilli V, Kfoury A, Mikaelian I, Renno T, Manié SN (April 2012). "LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation". Cell Death Dis. 3 (4): e300. doi:10.1038/cddis.2012.39. PMC 3358017. PMID 22513874.
• Zada S, Noh HS, Baek SM, Ha JH, Hahm JR, Kim DR (November 2015). "Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation". Cell Biol. Int. 39 (11): 1242–50. doi:10.1002/cbin.10497. PMID 26032166. S2CID 25267133.
• Wang L, Skotland T, Berge V, Sandvig K, Llorente A (February 2017). "Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation". Eur J Pharm Sci. 98: 80–85. doi:10.1016/j.ejps.2016.09.023. PMID 27664330. S2CID 28505134.
• Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J (April 2017). "Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling". Mol. Cell. Proteomics. 16 (4): 594–607. doi:10.1074/mcp.M116.064543. PMC 5383781. PMID 28174230.
• de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K (October 2017). "Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling". Science. 358 (6361): 377–381. Bibcode:2017Sci...358..377D. doi:10.1126/science.aao1583. PMID 28935770. S2CID 206662367.